Synthetic Kratom Derivatives: MGPI, MGM-15, and MGM-16
MGPI, MGM-15, MGM-16: similar-looking names can make the news hard to follow. Here’s where to start.
These aren’t strain names
MGPI, also called mitragynine pseudoindoxyl or MP, and MGM-15 and MGM-16 appear in DEA discussions about substances related to 7-OH. They refer to specific compounds. They aren’t catalog names like Bali or Maeng Da.
Keep the dates straight
DOJ’s October 9, 2026 update said August 26 controls on MGPI, MGM-15, and MGM-16 would remain during a new notice period. New notices were published October 14. The updated approach distinguishes MGM-15 and MGM-16 from a threshold-based approach proposed for 7-OH and MGPI. Follow the official documents for the scope of each action.
The word “natural” needs context
HHS said evidence about trace MGPI in botanical or kratom-derived material is still developing. That’s a reason to be precise, not to assume that every trace is synthetic or every product is safe. Botanical branding can’t verify the contents of an enhanced product.
Skip the promises of a workaround
A “research chemical” label or claims of a powerful new derivative don’t establish safety. Experience with leaf powder can’t tell you how an unfamiliar compound will affect you. This article explains the names; it doesn’t provide legal clearance, conversion recipes, or instructions for use.
Sources & further reading
For adults 21+. These guides offer general information, not personal medical or legal advice. For a question about your health, medicines, or legal situation, speak with a qualified professional.